Inflammation
Inflammation is an innate immune response to an irritation to the body causing symptoms: redness, heat, swelling, pain, and loss of function.

Inflammation aggravates fat disorders.

Reducing Inflammation

Many people with fat disorders find that reducing their inflammation lessens their pain and other symptoms.

One way inflammation can be reduced is by changing one's diet to be more acceptable to one's body. Please read the Nutrition page.

Another way is to make Lifestyle changes.

Some Lab Tests look for inflammation markers.

Acute Inflammation
Acute inflammation is a part of the healing process by rushing blood and its repair components to the irritation such as insect bites or sudden trauma such as sprains or blows.  The severity and number of the symptoms presenting also allows the medical practitioner to estimate damage and refer further treatments.  Generally, in acute inflammation, removing the source dissipates the effects of the response while creams, RICE (rest, ice, compress, elevate), or other anti-inflammatories relieve some of the response symptoms.  Especially in lipedema, some acute inflammation presents with very critical problems such as cellulitis and needs immediate medical response.

Chronic Inflammation
Chronic inflammation, sometimes called low-grade or sub-clinical, indicates an inflammation response that either lasts longer than the source, from an unknown source or is a self-damaging source.  In research, chronic inflammation may correlate to and may possibly causes cancer, autoimmune diseases, insulin resistance, coronary artery disease, gastric tract diseases, and many skin conditions (1) (2).

Some sources of chronic inflammation can include:

  • Any hidden or seen infection such as dental issues (gingivitis, decay)
  • Non-celiac gluten response and celiac response
  • GERD
  • Food intolerances along with food allergies
  • Histamine overloads or mast cell degranulation (3) (4)
  • Mast cell dysfunction
  • Autoimmune responses
  • Accumulation of adipose tissue and immune cells (5)

Recent research on inflammation found it to be a part of the function and dysfunction of the adipose tissue. As a function of adipose tissue, a number of pro-inflammatory chemicals are released through cross-talks with the immune cells and is used by the immune system to mount a defense from diseases/trauma.  As a dysfunction of the adipose tissue, several inflammatory cells infiltrate the adipose tissue and continually release pro-inflammatory chemicals while down regulating the adipose tissue’s ability to release anti-inflammatory chemicals.  When the cells die, macrophages infiltrate the adipose tissue and create a crown-like structure around the cell (6). Adipose tissue inflammation has other causes such as hypoxia and a high concentration of free fatty acids (7). Continued adipose tissue inflammation is now considered the first source of insulin resistance (7).

In modern medical knowledge, obesity (a collection of adipose tissue) is a chronic inflammation state of adipose tissue (8).  In some adipose tissue (fat) disorders, there is a collection in the subcutaneous hypodermis of hypertrophy and hyperplasia in soft or hard nodules.  While lipid energy stores do not effectively release with diet and exercise, the remaining functions of the adipose tissue remain active and may cause many of the same outcomes as diet-induced obesity (DIO) including obesity, which may put the patient into a chronic inflammatory state or highly insulin resistant state.  Various tests for causes of chronic inflammation, food intolerance, mast cell loads, and histamine overloads may be indicated and beneficial to the patient with an adipose tissue (fat) disorder.

 

References

1. "Chronic Tissue Inflammation: all immune cells on the stage"

Trends in Molecular Medicine

Volume 19, Issue 8, p 487-500

August 2013

http://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(13)00076-2?cc=y?cc=y

2. Scherer Lab - Home page

Touchstone Diabetes Center

http://www4.utsouthwestern.edu/schererlab/

3."Effects of Amine Oxidases in Allergic and Histamine-Mediated Conditions"

Mondovi, Bruno; A. Fogel, Wieslawa; Federico, Rodolfo; Calinescu, Carmen; A. Mateescu, Mircea; C. Rosa, Arianna; Masini, Emanuela 

Recent Patents on Inflammation & Allergy Drug Discovery, Volume 7, Number 1, January 2013, pp. 20-34(15)

http://www.ingentaconnect.com/content/ben/iad/2013/00000007/00000001/art00003

4. "Histamine and histamine intolerance"

Maintz, Laura and Novak, Natalija

American Society for Clinical Nutrition

2007

http://ajcn.nutrition.org/content/85/5/1185.long

 

5. "Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation"

Deng, Tuo, et al

DOI: http://dx.doi.org/10.1016/j.cmet.2013.02.009

http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00057-0

 

6. "Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration"

Journal of Cutaneous Pathology

J Cutan Pathol 2009: 36: 1293–1298

doi: 10.1111/j.1600-0560.2009.01256.x

http://www.cosmetic-medicine.jp/list/Suga-CUP2009.pdf

 

7." Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance, Role of the Adipocyte in Development of Type 2 Diabetes"

Po-Shiuan Hsieh (2011). Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance, Role of the Adipocyte in Development of Type 2 Diabetes, Dr. Colleen Croniger (Ed.), ISBN: 978-953-307-598-3, InTech, DOI: 10.5772/20561. Available from: http://www.intechopen.com/books/role-of-the-adipocyte-in-development-of-type-2-diabetes/obesity-induced-adipose-tissue-inflammation-and-insulin-resistance

http://www.intechopen.com/books/role-of-the-adipocyte-in-development-of-type-2-diabetes/obesity-induced-adipose-tissue-inflammation-and-insulin-resistance

 

8. "Obesity makes fat cells act like they're infected"

http://www.houstonmethodist.org/body.cfm?id=495&action=detail&ref=1003