Impact of hormones on adipose tissue
Given that lipedema tends to appear and become aggravated during hormonal shifts such as puberty, pregnancy, post partum and menopause, there is a clear link between hormones and lipedema. However very little is known about the link. It's worth noting that 7 cases  of men with lipedema have been reported and they all had low testosterone.
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(1) Presented by ?? at BLS Conference September 2013