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Dercum's disease is thought of as autosomal dominant +/- sex-specific influence.
MSL is inherited as a mitochondrial or unknown genetic mutation.
Lipedema is autosomal dominant with incomplete penetrance.
FML is autosomal dominant.
Several sources have reported the existence of a genetic link for lipedema, with a range between 16-64% of female family members also having lipedema . Two groups have been studying the genetic link, Dr Peter Mortimer in the UK  and a university in Pennsylvania .